Drug Discovery & Development - November 10, 2010
XOMA Ltd. announced that the U.S. Patent and Trademark Office today issued two new patents to XOMA as part of the company's expanding intellectual property portfolio around its XOMA 052 antibody to interleukin-1 beta (IL-1 beta). The patents cover methods of treatment for Type 1 diabetes and certain cancers, including multiple myeloma, using XOMA 052 or other IL-1 beta antibodies with similar binding characteristics to XOMA 052.
"These patents bring the total number of issued U.S. and European patents from the XOMA 052 program to eight," said Steven B. Engle, Chairman and Chief Executive Officer of XOMA. "We are succeeding in building a strong IP portfolio to protect our innovation around XOMA 052."
U.S. Patent 7,829,093 relates to methods of treating diabetes mellitus Type 1 with XOMA 052 or other IL-1 beta antibodies having similar binding properties. The second patent, U.S. 7,829,094, relates to methods of treating a cancer with XOMA 052 or other IL-1beta antibodies having similar binding properties, with the cancer being selected from multiple myeloma, acute myelogenous leukemia and chronic myelogenous leukemia. The patents provide coverage to 2026.
Three FDA-approved therapies that target the IL-1 pathway clinically validate the role of IL-1 in multiple diseases. These approved therapies and other IL-1 targeting drug candidates are in clinical development to address significant diseases including diabetes, cardiovascular disease, rheumatoid arthritis, gout and other inflammation-mediated diseases.
IL-1 beta is a pro-inflammatory cytokine recognized to be involved in the development of Type 2 diabetes, cardiovascular disease, rheumatoid arthritis, gout and other diseases. Through strong binding to IL-1 beta, XOMA 052 regulatesXOMA Issued Two New U.S. Patents Covering XOMA 052
Drug Discovery & Development - November 10, 2010
Date: November 9, 2010
Source: XOMA
"These patents bring the total number of issued U.S. and European patents from the XOMA 052 program to eight," said Steven B. Engle, Chairman and Chief Executive Officer of XOMA. "We are succeeding in building a strong IP portfolio to protect our innovation around XOMA 052."
U.S. Patent 7,829,093 relates to methods of treating diabetes mellitus Type 1 with XOMA 052 or other IL-1 beta antibodies having similar binding properties. The second patent, U.S. 7,829,094, relates to methods of treating a cancer with XOMA 052 or other IL-1beta antibodies having similar binding properties, with the cancer being selected from multiple myeloma, acute myelogenous leukemia and chronic myelogenous leukemia. The patents provide coverage to 2026.
Three FDA-approved therapies that target the IL-1 pathway clinically validate the role of IL-1 in multiple diseases. These approved therapies and other IL-1 targeting drug candidates are in clinical development to address significant diseases including diabetes, cardiovascular disease, rheumatoid arthritis, gout and other inflammation-mediated diseases.
IL-1 beta is a pro-inflammatory cytokine recognized to be involved in the development of Type 2 diabetes, cardiovascular disease, rheumatoid arthritis, gout and other diseases. Through strong binding to IL-1 beta, XOMA 052 regulatesXOMA Issued Two New U.S. Patents Covering XOMA 052
Drug Discovery & Development - November 10, 2010
XOMA Ltd. announced that the U.S. Patent and Trademark Office today issued two new patents to XOMA as part of the company's expanding intellectual property portfolio around its XOMA 052 antibody to interleukin-1 beta (IL-1 beta). The patents cover methods of treatment for Type 1 diabetes and certain cancers, including multiple myeloma, using XOMA 052 or other IL-1 beta antibodies with similar binding characteristics to XOMA 052.
"These patents bring the total number of issued U.S. and European patents from the XOMA 052 program to eight," said Steven B. Engle, Chairman and Chief Executive Officer of XOMA. "We are succeeding in building a strong IP portfolio to protect our innovation around XOMA 052."
U.S. Patent 7,829,093 relates to methods of treating diabetes mellitus Type 1 with XOMA 052 or other IL-1 beta antibodies having similar binding properties. The second patent, U.S. 7,829,094, relates to methods of treating a cancer with XOMA 052 or other IL-1beta antibodies having similar binding properties, with the cancer being selected from multiple myeloma, acute myelogenous leukemia and chronic myelogenous leukemia. The patents provide coverage to 2026.
Three FDA-approved therapies that target the IL-1 pathway clinically validate the role of IL-1 in multiple diseases. These approved therapies and other IL-1 targeting drug candidates are in clinical development to address significant diseases including diabetes, cardiovascular disease, rheumatoid arthritis, gout and other inflammation-mediated diseases.
IL-1 beta is a pro-inflammatory cytokine recognized to be involved in the development of Type 2 diabetes, cardiovascular disease, rheumatoid arthritis, gout and other diseases. Through strong binding to IL-1 beta, XOMA 052 regulates the activation of the IL-1 receptor, thereby inhibiting the cellular signaling events that produce inflammation.
Based on its binding properties, specificity for IL-1 beta and half-life, XOMA 052 may provide convenient dosing of once per month or less frequently.
XOMA is conducting two Phase 2 clinical trials of XOMA 052 in patients with Type 2 diabetes and a Phase 2 trial in Type 1 diabetes. XOMA 052 also has demonstrated positive clinical benefit in a proof-of-concept trial for the treatment of vision-threatening uveitis of Behcet's disease. XOMA 052 has been designated an orphan drug for the treatment of Behcet's disease by the U.S. Food and Drug Administration and the European Medicines Agency.
Date: November 9, 2010
Source: XOMA
the activation of the IL-1 receptor, thereby inhibiting the cellular signaling events that produce inflammation.
Based on its binding properties, specificity for IL-1 beta and half-life, XOMA 052 may provide convenient dosing of once per month or less frequently.
XOMA is conducting two Phase 2 clinical trials of XOMA 052 in patients with Type 2 diabetes and a Phase 2 trial in Type 1 diabetes. XOMA 052 also has demonstrated positive clinical benefit in a proof-of-concept trial for the treatment of vision-threatening uveitis of Behcet's disease. XOMA 052 has been designated an orphan drug for the treatment of Behcet's disease by the U.S. Food and Drug Administration and the European Medicines Agency."These patents bring the total number of issued U.S. and European patents from the XOMA 052 program to eight," said Steven B. Engle, Chairman and Chief Executive Officer of XOMA. "We are succeeding in building a strong IP portfolio to protect our innovation around XOMA 052."
U.S. Patent 7,829,093 relates to methods of treating diabetes mellitus Type 1 with XOMA 052 or other IL-1 beta antibodies having similar binding properties. The second patent, U.S. 7,829,094, relates to methods of treating a cancer with XOMA 052 or other IL-1beta antibodies having similar binding properties, with the cancer being selected from multiple myeloma, acute myelogenous leukemia and chronic myelogenous leukemia. The patents provide coverage to 2026.
Three FDA-approved therapies that target the IL-1 pathway clinically validate the role of IL-1 in multiple diseases. These approved therapies and other IL-1 targeting drug candidates are in clinical development to address significant diseases including diabetes, cardiovascular disease, rheumatoid arthritis, gout and other inflammation-mediated diseases.
IL-1 beta is a pro-inflammatory cytokine recognized to be involved in the development of Type 2 diabetes, cardiovascular disease, rheumatoid arthritis, gout and other diseases. Through strong binding to IL-1 beta, XOMA 052 regulates the activation of the IL-1 receptor, thereby inhibiting the cellular signaling events that produce inflammation.
Based on its binding properties, specificity for IL-1 beta and half-life, XOMA 052 may provide convenient dosing of once per month or less frequently.
XOMA is conducting two Phase 2 clinical trials of XOMA 052 in patients with Type 2 diabetes and a Phase 2 trial in Type 1 diabetes. XOMA 052 also has demonstrated positive clinical benefit in a proof-of-concept trial for the treatment of vision-threatening uveitis of Behcet's disease. XOMA 052 has been designated an orphan drug for the treatment of Behcet's disease by the U.S. Food and Drug Administration and the European Medicines Agency.
Date: November 9, 2010
Source: XOMA
the activation of the IL-1 receptor, thereby inhibiting the cellular signaling events that produce inflammation.
Based on its binding properties, specificity for IL-1 beta and half-life, XOMA 052 may provide convenient dosing of once per month or less frequently.
Date: November 9, 2010
Source: XOMA
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